PlasmidFactory | Literatur

M. Izco, M. Schleef, M. Schmeer, E. Carlos, G. Verona and L. Alvarez-Erviti (2023), Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord, Pharmaceutics. 2023; 15(4):1230.
R. Shankar, N. Schäffer, C. Krüsemann, M. Schmeer, M. Schleef (2022), In-process controls for plasmid isoform characterization, Abstract ESGCT 29th Annual Congress in collaboration with BSGCT Edinburgh, online
D. Lock , R. Monjezi, C. Brandes , S. Bates, S. Lennartz, K. Teppert , L. Gehrke, R. Karasakalidou-Seidt, T. Lukic, M. Schmeer, M. Schleef, N. Werchau, M. Eyrich , M. Assenmacher, A. Kaiser, S. Prommersberger, T. Schaser, M. Hudecek (2022), Automated, scaled, transposon-based production of CAR T cells, Journal for Immuno Therapy of Cancer
S. Prommersberger, R. Monjezi, R. Shankar, M. Schmeer, M. Hudecek, Z. Ivics et al. (2022), Minicircles for CAR T Cell Production by Sleeping Beauty Transposition: A Technological Overview, Gene Therapy Of Cancer – Methods and Protocols
M. Schmeer, M. Schleef, R. Shankar, D. Kobelt, W. Walther (2022), Capillary Gel Electrophoresis (CGE) for Quality Control of Plasmid DNA in Gene Therapy: Quality Control of 20 Years Stored GMP-Grade Plasmid DNA, Gene Therapy Of Cancer – Methods and Protocols
R. Shankar, N. Schäffer, M. Schmeer, J.M. Risse, K. Friehs & M. Schleef (2021), Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification., Microb Cell Fact 20, 171 (2021)
María Izco, Javier Blesa, Martin Schleef, Marco Schmeer et al. (2019), Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology, Molecular Therapy Vol. 27 No 12
T. Buchholz, M. Schleef (2018), Classification and Regulation of Advanced Therapy Medicinal Products, International Biopharmaceutical Industry, Volume 1 Issue 3, 44-45, Winter 2018
T. Buchholz, C.J. Christel and H. Besir (2018), Customised Viral Engineering - Proactive Progress, European Biopharmaceutical Review, April, 24-31.
M. Holstein, C. Mesa-Nuñez, C. Miskey et al. (2018), Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors, Molecular Therapy Vol. 26 No 4, 1137-1153, April 2018
T. Buchholz, M. Schmeer and M. Schleef (2017), Size Matters, European Biopharmaceutical Review, October, 68-70.
M. Schmeer, T. Buchholz and M. Schleef (2017), Plasmid DNA Manufacturing for Indirect and Direct Clinical Applications, Human Gene Therapy, 28(10):856-861.
R. Shankar, M. Schmeer and M. Schleef (2017), Minicircles: next-generation gene vectors, Cell Gene Therapy Insights 2017;3(2), 285-300.
Wiebke Garrels, Thirumala R. Talluri, Maren Ziegler, Ilka Most, Diego O. Forcato, Marco Schmeer, Martin Schleef, Zoltán Ivics und Wilfried A. Kues (2016), Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice, www.biotechnology-journal.com
M. Schnödt, M. Schmeer, B. Kracher, C. Krüsemann, L. E. Espinosa, A. Grünert, T. Fuchsluger, A. Rischmüller, M. Schleef and H. Büning (2016), DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations, Molecular Therapy—Nucleic Acids, 5, e355.
R. Monjezi, C. Miskey, T. Gogishvili, M. Schleef, M. Schmeer, H. Einsele, Z. Ivics and M. Hudecek (2016), Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors, Leukemia, 1-9.
I. Freudenau, P. Lutter, R. Baier, M.Schleef , H. Bednarz , A. R. Lara and K. Niehaus (2015), ColE1-plasmid production in Escherichia coli: mathematical simulation and experimental validation, Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2015.00127.
H. Akita, D. Kurihara, M.Schmeer, M. Schleef and H. Harashima (2015), Effect of the Compaction and the Size of DNA on the Nuclear Transfer Efficiency after Microinjection in Synchronized Cells, Pharmaceutics, 10.3390/pharmaceutics7020064.
M. Schmeer, M. Schleef (2014), Pharmaceutical Grade Large-Scale Plasmid DNA Manufacturing Process, in: M. Rinaldi et al. (eds), Methods in Molecular Biology, DNA Vaccines, vol. 1143, 219-240.
D. Kolbelt, M. Schleef, M. Schmeer, J. Aumann, P.M. Schlag, W. Walther (2013), Performance of High Quality Minicircle DNA for In Vitro and In Vivo Gene Transfer, Mol. Biotechnol., 53 (1), 80-89.
S. Chabot, J. Orio, M. Schmeer, M. Schleef, M. Golzio, J. Teissié (2013), Minicircle DNA Electrotransfer for efficient Tissue targeted Gene Delivery, Gene Therapy 20 (1), 62-68.
M. Viefhues, S. Wegener, A. Rischmüller, M. Schleef and D. Anselmetti (2013), Dielectrophoresis based continuous-flow nano sorter: fast quality control of gene vaccines, Lab Chip, 13 3111-3118.
M. Schleef (2013), Non Viral DNA Vectors, In: D. Scherman (ed.), Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology – Principles, Delivery and Pharmacology and Biomedical Application of Nucleotide-Based Therapies, Imperial College Press London, 183-205.
M. Schleef (2013), Production and Purification of Plasmid Vectors, In: D. Scherman (ed.), Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology – Principles, Delivery and Pharmacology and Biomedical Application of Nucleotide-Based Therapies, Imperial College Press London, 517-525.
W. Walther, M. Schmeer, D. Kobelt, R. Baier, A. Harder, V. Walhorn, D. Anselmetti, J. Aumann, I. Fichtner, M. Schleef (2013), A seven-Year Storage Report of Good Manufacturing Practice-Grade Naked Plasmid DNA: Stability, Topology, and In Vitro/In Vivo Functional Analysis, HGT Clin. Dev. 24, 147-153.
M. Schleef (ed.) (2013), Minicircle and Miniplasmid DNA Vectors, The Future of Non-Viral and Viral Gene Transfer, Wiley-VCH Weinheim, ISBN 978-3-527-32456-9.
M. Schleef, M. Blaesen, M. Schmeer, R. Baier, C. Marie, G. Gickson, D. Scherman (2010), Production of non viral DNA Vectors, Current Gene Therapy, 10, 487-507.
M. Schmeer (2009), Electroporative Gene Transfer, in: W. Walther and U. S. Stein (eds), Methods in Molecular Biology, Gene Therapy of Cancer, vol. 542, 157-165.
M. Schleef, M. Blaesen (2009), Production of Plasmid DNA as a Phamaceutical, in: W. Walther and U. S. Stein (eds), Methods in Molecular Biology, Gene Therapy of Cancer, vol. 542, 471-495.
C. Maucksch, A. Bohla, F. Hoffmann, M. Schleef, M. K. Aneja, M. Elfinger, D. Hartl, C. Rudolph (2009), Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cells, J Gene Med 11: 444-453.
M. Schleef, R. Baier, W. Walther, M.L. Michel, and M. Schmeer (2006), Long-Term Stability Study and Topology Analysis of Plasmid DNA By Capillary Gel Electrophoresis, BioProcess International, 38-40.
M. Schleef (ed.) (2005), DNA-Pharmaceuticals, Wiley-VCH Weinheim, ISBN 3-527-31187-4.

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